Ceci est une ancienne révision du document !
Sommaire
Maladie d'Alzheimer : évaluation de l'acupuncture
1. Revues systématiques et méta-analyses
1.1. Zou 2016☆
Zou Jingfeng, Guo Peiyan, Xie Ke, Dong Xushuai, Zhao Fei. [Meta-analysis of the effectiveness of acupuncture treatment combined with traditional chinese medicine treatment of Alzheimer disease]. China Journal of Chinese Medicine. 2016;1:138-143. [186905]. [Traduction automatique]
| Automatic translation | |
| Objectives | comparer la maladie d’Alzheimer traitée par acupuncture combinés avec la médecine traditionnelle chinoise et l’efficacité de la médecine traditionnelle chinoise. |
|---|---|
| Methods | Recherche PubMed, Embase, SA base de données et des journaux étrangers, filtrent l’acupuncture contrôlée randomisée contrôlée des essais cliniques de médecine traditionnelle chinoise pour le traitement de la maladie d’Alzheimer seule. Pour répondre aux normes de qualité de l’évaluation de la littérature et en utilisant RevMan Manager 5. 2 logiciel Meta analysis. |
| Results | inclus au total y compris 335 cas 6 références. Méta-analyse montre que l’acupuncture et à l’aide de la médecine traditionnelle chinoise pour le traitement de la maladie d’Alzheimer, le taux effectif était de 76. 96 % à 65 ans. 28 %, l’effet combiné du ratio d’OR = 1. 89, (IC À 95 % = 1. 11, 3. 21), P = 0. 02 < 0. 05, ce qui indique une différence statistiquement significative ; l’acupuncture et à l’aide de la médecine traditionnelle chinoise dans le traitement de la maladie d’Alzheimer après l’ESGI, échelle ADL scores résultats pour MD = 1. 55, (IC À 95 % = 0. 98, 2. 12), P < 0. 01、WMD 000 = 0. 36, (IC À 95 % = 0. 14, 0. 59), P = 0. 002, résultats surtout < 0. 05, notes sur les modifications apportées avant et après traitement de l’acupuncture et la médecine avec la comparaison de l’effet curatif de la médecine traditionnelle chinoise seule, qu'il n’y avait aucune différence statistiquement significative. |
| Conclusions | l’acupuncture a un avantage par rapport à l’aide de la médecine traditionnelle chinoise dans le traitement de la maladie d’Alzheimer, mais il faut encore plus grande échelle, randomisée de haute qualité contrôlée des essais pour vérification supplémentaire. |
1.2. Zou 2016 ∼
Zou Jingfeng, Xie Ke, Guo Peiyan, Dong Xushuai, Zhao Fei. [Meta-analysis of randomized controlled clinical trial about acupuncture in treating Alzheimer's disease]. Gansu Journal of Traditional Chinese Medicine. 2016;1:80-84. [186969].
| Objectives | To systematically assess the differences between traditional acupuncture and western medicine in treating alzheimer's disease. |
|---|---|
| Methods | Randomized controlled trials (RCTs) about acupuncture compared with western medicine in treating alzheimer's disease were chosen by searching PubMed, Embase, Cochrane library, CNKI, VIP and Wanfang, the quality of the literature which met the included standard were assessed and meta-analysis was performed by using RevMan 5. 2 software. |
| Results | Eight articles and 349 patients were included. The results of Meta-analysis showed that the difference had no statistical meaning between both groups, while clinical effects of acupuncture in treating alzheimer's disease [OR=1. 15, 95%CI (0. 69, 1. 91)], MMSE scaling [MD=0. 40, 95%CI (-2. 18, 2. 97)], ADL scaling [MD=0. 60, 95%CI (-0. 54, 1. 74)], HDS scaling [MD=-0. 20, 95%CI (-1. 19, 0. 80)] were equivalent to these indexes of western medicine. |
| Conclusions | The advantages of acupuncture in treating alzheimer's disease compared with western medicine are unsure, more large samples and high quality RCTs are needed to further validate the results. |
1.3. Xu 2015 (association au traitement médicamenteux) ☆☆
Xu Xiaotai, Xie Wei. [Meta-analysis on acupuncture combined with western medicine for treatment of Alzheimer’s disease]. World Science and Technology-Modernization of Traditional Chinese Medicine. 2015;4:836-840. [187068].
| Objectives | This study was aimed to evaluate efficacy of acupuncture combined with western medicine in treatment of Alzheimer’s disease (AD) with meta-analysis of data came from randomized controlled trials (RCTs). |
|---|---|
| Methods | Databases both at home and abroad were comprehensively searched to collect efficacy data of acupuncture combined with western medicine versus western medicine in RCTs. The data was extracted from each study to conduct a meta-analysis with Rev Man 5. 2. |
| Results | The results showed that 10 studies measured up to standard. Seven studies reported effective cases were carried out by meta-analysis. The total RR was 1. 25 [1. 14, 1. 38]. The funnel plot was approximately symmetry. It was suggested that effect of the therapy group was better than the control group (Z = 4. 66, P<0. 01). Four studies reported mini-mental state examination (MMSE) scores were carried out by meta-analysis. The total MD was 2. 87 [0. 64, 5. 10]. The funnel plot was approximately symmetry. It was suggested that the therapy group was better than the control group on AD treatment in cognitive function improvement (Z = 2. 52, P= 0. 01). |
| Conclusions | It was concluded that from current study, acupuncture combined with western medicine in AD treatment was definitely effective. However, it still required further study. |
1.4. Zhou 2015 ☆☆
Zhou J, Peng W, Xu M, Li W, Liu Z. The Effectiveness and Safety of Acupuncture for Patients with Alzheimer Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Medicine (Baltimore). 2015;94(22). [183449].
| Objectives | The use of acupuncture for treating Alzheimer disease (AD) has been increasing in frequency over recent years. As more studies are conducted on the use of acupuncture for treating AD, it is necessary to re-assess the effectiveness and safety of this practice. The objective of this study was to assess the effectiveness and safety of acupuncture for treating AD. |
|---|---|
| Methods | Central Register of Controlled Trials (CENTRAL), PubMed, MEDLINE, Embase, PsycINFO, Chinese Biomedicine Literature (CBM), Chinese Medical Current Content (CMCC) and China National Knowledge Infrastructure (CNKI) were searched from their inception to June 2014. Randomized controlled trials (RCTs) with AD treated by acupuncture or by acupuncture combined with 1 kind of drugs were included. Two authors extracted data independently. The continuous data were expressed as mean differences (MD) with 95% confidence intervals (Cis). Weighted MD (WMD) was used instead of standardized MD (SMD) when the same scales were used. Adverse reactions related to acupuncture were also investigated. |
| Results | Ten randomized controlled trials with a total of 585 participants were included in the meta-analysis. The combined results of 6 trials showed that acupuncture was better than drugs at improving scores on the Mini Mental State Examination (MMSE) scale (MD 1.05, 95% CI 0.16-1.93). Evidence from the pooled results of 3 trials showed that acupuncture plus donepezil was more effective than donepezil alone at improving the MMSE scale score (MD 2.37, 95% CI 1.53-3.21). Out of 141 clinical trials, 2 trials reported the incidence of adverse reactions related to acupuncture. Seven out of 3416 patients had adverse reactions related to acupuncture during or after treatment; the reactions were described as tolerable and not severe |
| Conclusions | Acupuncture may be more effective than drugs and may enhance the effect of drugs for treating AD in terms of improving cognitive function. Acupuncture may also be more effective than drugs at improving AD patients' ability to carry out their daily lives. Moreover, acupuncture is safe for treating people with AD |
1.5. Cao 2014 Ø
Cao Fei, Pan Xiao-Ling, Li Xuan-Chao, Chen Bao, Jin Yuan, Huang Peng. [Systematic review and meta-analysis on acupuncture for Alzheimer disease in chinese population]. Acta Academiae Medicinae Jiangxi. 2014;9:59-61, 6. [186901].
| Objectives | To assess the therapeutic effect of acupuncture on Alzheimer disease (AD)in Chinese population, and to provide more reliable information for the treatment of AD. |
|---|---|
| Methods | The literature published from January 1979 to December 2013 on the acupuncture for treatment of Alzheimer disease in Chinese population was collected, and the effects of acupuncture on mini-mental state examination (MMSE) and activity of daily living (ADL) were assessed. The meta-analysis was conducted by using RevMan5. 0. |
| Results | A total of 5 randomized controlled trials were identified and all controls were oral medications. In the aspect of cognitive function, the weighted mean difference (WMD)was -0. 61 (- 1. 34, 0. 13). In the aspect of ADL, the WMD was -0. 48 (-0. 72, 0. 76). |
| Conclusions | Compared with oral medications, the acupuncture can not improve the MMSE and ADL scores in patients with AD. Furthermore, the quality of literature is poor. Therefore, more observations are needed to verify the effect of acupuncture on AD. |
1.6. Lee 2009
Lee MS, Shin BC, Ernst E. Acupuncture for Alzheimer's disease: a systematic review. Int J Clin Pract. 2009;63(6):874-9. [153322].
| Background | Acupuncture is often used as a treatment for dementia and is claimed to be effective in improving intelligence. |
|---|---|
| Aims | The objective of this review is to assess the clinical evidence for or against acupuncture as a treatment for Alzheimer's disease (AD). |
| methods | We searched the literature using 17 databases from their inception to August 2008, without language restrictions. We included all randomised clinical trials (RCTs) of needle acupuncture to treat human patients suffering from AD. Methodological quality was assessed using the Jadad score. |
| Results | Three RCTs met all inclusion criteria. Two RCTs assessed the effectiveness of acupuncture on cognitive function compared with drug therapy. Their results suggested no significant effect in favour of acupuncture [n = 72, weight mean difference (WMDs), -0.55; 95% confidence intervals (CIs) -1.31 to 0.21, p = 0.15, heterogeneity: tau(2) = 0, chi(2) = 0.048, p = 0.49, I(2) = 0%]. Two RCTs tested acupuncture for activities of daily living (ADL). One RCT reported favourable effects of drug therapy compared with acupuncture for ADL, while the other failed to so. The meta-analysis of these data showed significant effects of drug therapy compared with acupuncture (n = 72, WMD, -1.29; 95% CIs: -1.77 to -0.80, p < 0.001, heterogeneity: tau(2) = 0, chi(2) = 0.17, p = 0.68, I(2) = 0%). |
| Conclusion | Even though the number of studies is small, the existing evidence does not demonstrate the effectiveness of acupuncture for AD. |
