目的 评价针刺治疗绝经后骨质疏松症的有效性及安全性.方法 电子检索中文和英文数据库共6个,检索日期截至2017年11月,根据Cochrane Hand book 5.3评价标准和工具评价纳入研究的质量,并用Revman 5.3软件进行Meta分析.结果 共纳入10篇文献,包括710例患者,试验组354例,对照组356例.Meta分析显示:①针刺vs常规治疗[RR=1.36,95%CI(1.18,1.57),Z=4.34,P<0.0001]、针刺+常规治疗vs常规治疗[RR=1.31,95%CI(1.14,1.50),Z=3.77,P=0.0002],在提高临床有效率上均优于对照组;②针刺vs常规治疗[MD=-2.36,95%CI(-4.20,-0.53),Z=2.53,P=0.01]、针刺+常规治疗vs常规治疗[MD=-1.61,95%CI(-2.06,-1.16),Z=7.01,P<0.00001],在改善疼痛评分上均优于对照组.结论 与单用常规治疗相比,针刺或针刺联合常规治疗在提高临床治疗有效率、改善疼痛方面疗效更优,适于临床采纳应用.但考虑到纳入文献的局限性,在今后的研究中需要更多高质量、大样本、多中心、方法学设计严谨的随机对照试验,进一步佐证并提升针刺治疗绝经后骨质疏松症有效性和安全性证据强度 |
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Objective | To evaluate the efficacy and safety of acupuncture for postmenopausal osteoporosis. |
Methods | A total of 6 Chinese and English databases were searched electronically. The search date was as of November 2017, and was included in the study according to Cochrane Hand book 5.3 evaluation criteria and tools. Quality, and meta-analysis using Revman 5.3 software. |
Results | The results included 10 articles, including 710 patients, 354 patients in the experimental group, and 356 patients in the control group. Meta-analysis showed: 1 acupuncture vs conventional therapy [RR=1.36, 95% CI (1.18, 1.57), Z=4.34, P<0.0001], acupuncture + conventional treatment vs conventional treatment [RR=1.31, 95% CI (1.14, 1.50), Z=3.77, P=0.0002], in clinical improvement Efficiency is better than the control group; 2 acupuncture vs conventional treatment [MD = -2.36, 95% CI (-4.20, -0.53), Z = 2.53, P = 0.01], acupuncture + conventional treatment vs conventional treatment [MD =-1.61, 95% CI (-2.06, -1.16), Z=7.01, P<0.00001], superior to the control group in improving pain score. |
Conclusion | Acupuncture or acupuncture combined with conventional treatment alone Conventional treatment is more effective in improving clinical treatment efficiency and improving pain, and is suitable for clinical adoption. However, considering the limitations of the included literature, more high quality and large need are needed in future research. Sample, multicenter, methodologically designed randomized controlled trials to further corroborate and enhance the efficacy and safety of acupuncture for postmenopausal osteoporosis. |