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acupuncture:evaluation:rhumatologie - orthopedie:03. fibromyalgie [25 Jun 2021 09:32] Pernice Claude [Fibromyalgie : évaluation de l'acupuncture] |
acupuncture:evaluation:rhumatologie - orthopedie:03. fibromyalgie [15 Jun 2025 16:34] (Version actuelle) Nguyen Johan [3. Clinical Practice Guidelines] |
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| ===== Systematic Reviews and Meta-Analysis===== | ===== Systematic Reviews and Meta-Analysis===== | ||
| - | |★★★ |Evidence for effectiveness and a specific effect of acupuncture. | | + | |
| - | |★★| Evidence for effectiveness of acupuncture.| | + | |
| - | | ★ |Limited evidence for effectiveness of acupuncture. | | + | |
| - | |Ø |No evidence or insufficient evidence.| | + | |
| + | ==== Ye 2024 ==== | ||
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| + | Ye G, Miao R, Chen J, Huang J, Jiang M. Effectiveness of Complementary and Alternative Medicine in Fibromyalgia Syndrome: A Network Meta-Analysis. J Pain Res. 2024 Jan 20;17:305-319. https://doi.org/10.2147/JPR.S439906 | ||
| + | ^Objective| Fibromyalgia (FM) is a prevalent chronic disorder characterized by widespread skeletal muscle pain. In recent years, complementary and alternative medicine (CAM) has increasingly been recognized for its potential in treating FM symptoms. This study aims to assess the efficacy of CAM therapies in mitigating the symptoms of FM.| | ||
| + | ^Methods| This systematic review was registered with INPLASY. A thorough search of both English and Chinese databases was undertaken from their inception until April 15, 2023. The search criteria focused on prospective controlled trials examining CAM therapies in FM patients. The statistical analysis employed mean values and standard deviations. Additionally, an evaluation of the literature's quality and potential biases was conducted.| | ||
| + | ^Results| The search yielded 41 articles, encompassing 2877 FM patients and involving 20 different interventions. All studies were randomized controlled trials (RCTs). The results of the network meta-analysis (NMA) indicated that a combination of Acupuncture and Massage therapy, as well as Navel Needling therapy, effectively alleviated pain symptoms in FM patients. Furthermore, Abdominal Acupuncture and Electroacupuncture were found to be beneficial in improving patients' mood and sleep quality.| | ||
| + | ^Conclusion| Acupuncture + Massage and Umbilical Acupuncture emerged as the most efficacious therapies in relieving pain symptoms in FM patients. Abdominal Acupuncture and Electroacupuncture demonstrated their effectiveness in enhancing mood and sleep quality. Overall, CAM therapies exhibited a high safety profile for patients with fibromyalgia.| | ||
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| + | |||
| + | ==== Almutari 2022 ★★★ ==== | ||
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| + | Almutairi NM, Hilal FM, Bashawyah A, Dammas FA, Yamak Altinpulluk E, Hou JD, Lin JA, Varrassi G, Chang KV, Allam AE. Efficacy of Acupuncture, Intravenous Lidocaine, and Diet in the Management of Patients with Fibromyalgia: A Systematic Review and Network Meta-Analysis. Healthcare (Basel). 2022 Jun 23;10(7):1176. https://doi.org/10.3390/healthcare10071176. | ||
| + | ^Introduction| This network meta-analysis aimed to assess the efficacy of acupuncture, intravenous lidocaine, and diet compared with other comparators such as physiotherapy and sham/placebo in fibromyalgia patients. | | ||
| + | ^Materials and Methods| We searched Embase, PubMed, Scopus, and Web of Science for relevant studies till September 2021. The included studies were randomized controlled clinical trials. For the network meta-analysis, we used the R software. | | ||
| + | ^Results| There were 23 included RCTs. The total sample size was 1409 patients. Compared with the sham/placebo group, the network analysis showed the highest improvement in the quality of life in the acupuncture group standardized mean difference (SMD) = -10.28, 95%-CI [-14.96; -5.59]), and then in the physiotherapy group (SMD = -7.48, 95%-CI [-14.72; -0.23]). For the pain, there was a significant reduction with acupuncture (SMD = -1.69, 95%-CI [-2.48; -0.89]), compared with sham/placebo. Regarding depression, it showed a significant reduction with acupuncture (SMD = -9.64, 95%-CI [-16.13; -3.14]) compared with sham/placebo. Finally, for stiffness, it showed no significant differences in the stiffness between acupuncture (SMD = -8.52, 95%-CI [-20.40; 3.36]), fluoxetine (SMD = -6.52, 95%-CI [-29.65; 16.61]), and physiotherapy (SMD = -4.64, 95%-CI [-22.83; 13.54]) compared with sham/placebo. | | ||
| + | ^Conclusions| The acupuncture showed a significant effect in the management of fibromyalgia patients. It reduced pain, depression, and enhanced the quality of life. While physiotherapy showed a significant improvement in the quality of life only. In contrast, intravenous lidocaine and diet showed no significant differences when compared with sham/placebo.| | ||
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| + | |||
| + | ==== Valera-Calero 2022 ★★==== | ||
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| + | Valera-Calero JA, Fernández-de-Las-Peñas C, Navarro-Santana MJ, Plaza-Manzano G. Efficacy of Dry Needling and Acupuncture in Patients with Fibromyalgia: A Systematic Review and Meta-Analysis. Int J Environ Res Public Health. 2022 Aug 11;19(16):9904. https://doi.org/10.3390/ijerph19169904 | ||
| + | ^Background|Fibromyalgia (FM) is a syndrome that involves chronic pain, fatigue, sleep disturbance and impaired quality of life and daily functioning. In addition to medical and psychological therapies, other therapies including acupuncture and dry needling aim to reduce pain and disability in patients with FM. The aim of this study was to investigate the efficacy of dry needling and acupuncture in patients with FM regarding pain, function and disability in both the short and the long term. | | ||
| + | ^Method|MEDLINE, PubMed, SCOPUS and Web of Science databases were systematically searched for randomized controlled trial studies evaluating efficacy data of dry needling or/and acupuncture treatments to improve pain, fatigue, sleep disturbance and impaired quality of life and/or daily function. A qualitative analysis including the methodological quality and a systematic data synthesis was performed.| | ||
| + | ^Results| A total of ** 25 studies** addressed the selection criteria. Most studies had an acceptable methodological quality. Four studies assessed the effect of dry needling, and twenty-one studies assessed the effect of acupuncture. In general, both interventions improved pain, anxiety, depression, fatigue, stiffness, quality of sleep and quality of life. However, both techniques were not compared in any study.| | ||
| + | ^Conclusions| Acupuncture and dry needling therapies seems to be effective in patients with FM, since both reduced pain pressure thresholds, anxiety, depression, fatigue, sleep disturbances and disability in the short term. It is still required to compare both techniques and their application in the long term.| | ||
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| + | |||
| + | ==== Zheng 2022 ★★★ ==== | ||
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| + | |||
| + | Zheng C, Zhou T. Effect of Acupuncture on Pain, Fatigue, Sleep, Physical Function, Stiffness, Well-Being, and Safety in Fibromyalgia: A Systematic Review and Meta-Analysis. J Pain Res. 2022 Feb 3;15:315-329. https://doi.org/10.2147/JPR.S351320 | ||
| + | ^Purpose|Fibromyalgia (FM) is a syndrome characterized by widespread pain, which caused huge economic and social burden. Acupuncture is often used to manage chronic pain. However, the efficacy of acupuncture in FM is still controversial. This study aimed to systematically review the effects of acupuncture on pain, fatigue, sleep quality, physical function, stiffness, well-being, and safety in FM.| | ||
| + | ^Methods| We searched databases including PubMed, Embase, the Cochrane Library, Wanfang Database, Chongqing Weipu, and the China National Knowledge Infrastructure from inception to September 2021. Eligible studies included randomized or quasi-randomized controlled studies of acupuncture in patients with FM. Quantitative analysis was conducted using RevMan 5.3 software, and risk assessment was performed according to the Cochrane collaboration tool. Safety was quantitatively analyzed.| | ||
| + | ^Results|A total of **13 articles** were searched, of which 12 were analyzed quantitatively. Our meta-analysis found that acupuncture could alleviate pain (SMD: -0.42, 95% CI, -0.66, -0.17, P<0.001, I2=58%) and improve well-being (SMD: -0.86, 95% CI, -1.49, 0.24, P=0.007, I2=85%) at post-treatment. In addition, acupuncture showed long-term effects on reducing pain (P=0.03) and improving well-being (P<0.001). No evidence that acupuncture works on fatigue, sleep quality, physical function, or stiffness was found. No serious adverse events were detected in acupuncture treatment.| | ||
| + | ^Conclusion| Moderate quality of evidence supports acupuncture in reducing pain in patients with FM. Therefore, acupuncture is recommended as a treatment for FM.| | ||
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| <wrap lo>Fibromyalgia is a chronic-pain-related syndrome associated with high rates of complementary and alternative medicine (CAM) use. Among the many CAM therapies frequently used by fibromyalgia patients, empirical research data exist to support the use of only three: (1) mind-body, (2) acupuncture, and (3) manipulative therapies for treating fibromyalgia. The strongest data exist for the use of mind-body techniques (e.g. biofeedback, hypnosis, cognitive behavioural therapy), particularly when utilized as part of a multidisciplinary approach to treatment. The weakest data exist for manipulative techniques (e.g. chiropractic and massage). **The data supporting the use of acupuncture for fibromyalgia are only moderately strong**. Also, for some fibromyalgia patients, acupuncture can exacerbate symptoms, further complicating its application for this condition. Further research is needed not only in these three areas, but also for other treatments being frequently utilized by fibromyalgia patients. | <wrap lo>Fibromyalgia is a chronic-pain-related syndrome associated with high rates of complementary and alternative medicine (CAM) use. Among the many CAM therapies frequently used by fibromyalgia patients, empirical research data exist to support the use of only three: (1) mind-body, (2) acupuncture, and (3) manipulative therapies for treating fibromyalgia. The strongest data exist for the use of mind-body techniques (e.g. biofeedback, hypnosis, cognitive behavioural therapy), particularly when utilized as part of a multidisciplinary approach to treatment. The weakest data exist for manipulative techniques (e.g. chiropractic and massage). **The data supporting the use of acupuncture for fibromyalgia are only moderately strong**. Also, for some fibromyalgia patients, acupuncture can exacerbate symptoms, further complicating its application for this condition. Further research is needed not only in these three areas, but also for other treatments being frequently utilized by fibromyalgia patients. | ||
| </wrap> | </wrap> | ||
| + | |||
| + | ==== Special Acupuncture Techniques ==== | ||
| + | === Cupping === | ||
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| + | == Salazar-Méndez 2023 == | ||
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| + | Salazar-Méndez J, Cancino-Valderrama V, Aguilar-Román G, Guzmán-Muñoz E. Efficacy of cupping therapy in individuals with fibromyalgia. A systematic review of randomized clinical trials. J Bodyw Mov Ther. 2023 Oct;36:256-262. https://doi.org/10.1016/j.jbmt.2023.04.088 | ||
| + | ^Backgound| Fibromyalgia is a chronic and idiopathic condition and is among the most common causes of generalized chronic pain, even affecting psychological and cognitive aspects.| | ||
| + | ^Aim| To evaluate the efficacy of cupping therapy on pain, quality of life, sleep disorders, and the impact of the disease in subjects with fibromyalgia.| | ||
| + | ^Methods| We searched the Pubmed, CINAHL, Epistemonikos, Scopus, and Web of Science databases. Randomized controlled trials involving adults with fibromyalgia undergoing cupping were included. Pain intensity, quality of life, sleep disturbances, and the impact of fibromyalgia were assessed. We have reported the results using descriptive statistics and narrative synthesis.| | ||
| + | ^Results| Two articles with a total of 155 participants were included. Large effect sizes were found for pain intensity, moderate for quality of life, and low for the impact of fibromyalgia and sleep disorders. However, the certainty of the evidence is low for most outcomes except for sleep disorders.| | ||
| + | ^Conclusions| There is a discrepancy in the efficacy of cupping therapy in improving pain intensity, quality of life, sleep disturbances, and disease impact in people with fibromyalgia. Future high-quality randomized clinical trials are required.| | ||
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| ===== Overviews of Systematic Reviews ===== | ===== Overviews of Systematic Reviews ===== | ||
| + | |||
| + | ==== Araya-Quintanilla 2024 ==== | ||
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| + | Araya-Quintanilla F, Ramirez-Vélez R, Mendez-Rebolledo G, Cuyul-Vásquez I, Arce-Álvarez A, Ezzatvar Y, Gutiérrez-Espinoza H. Effects of acupuncture versus placebo on clinical status and potential specific effects in Fibromyalgia: an umbrella review of 11 meta-analyses. Ther Adv Musculoskelet Dis. 2024 Aug 20;16:1759720X241271775. https://doi.org/10.1177/1759720X241271775 | ||
| + | ^Backgound| The use of acupuncture is related to patients' expectations, and the therapeutic interaction effect remains a topic of debate in the literature. Accordingly, it is still unclear whether acupuncture can generate positive clinical effects in patients with fibromyalgia (FM).| | ||
| + | ^Objective| To determine the effectiveness of acupuncture versus placebo for clinical outcomes and determine the overall effect not attributed to specific effects in patients with FM.| | ||
| + | ^Design| Umbrella review of systematic reviews (SRs) and meta-analyses.| | ||
| + | ^Data sources and methods|An electronic search was performed in MEDLINE (via PubMed), Web of Science, CENTRAL, EMBASE, LILACS, CINAHL, PEDro, and SPORTDiscus databases from inception until December 2023. We selected studies with a clinical diagnosis of FM and that analyzed the effectiveness of acupuncture compared with a placebo. Pain intensity, functional status, fatigue, sleep quality, and depression symptoms were assessed. Effect sizes were calculated as the mean difference (MD) or standard mean difference (SMD). The quality of intervention reporting was assessed using the Grading of Recommendations Assessment, Development, and Evaluation approach.| | ||
| + | ^Results| **Eleven SRs with 8399 participants** were included. Compared with placebo, acupuncture was associated with reductions in pain intensity (MD = -1.13 cm, 95% CI -2.09 to -0.17, p < 0.001), physical function (SMD = -0.63, 95% CI -1.67 to 0.41, p = 0.06), sleep quality (SMD = -0.25, 95% CI -1.39 to 0.88, p = 0.06), and fatigue (SMD = 0.20, 95% CI = 0.17 to 0.22, p < 0.001). The proportion not attributable to specific effects (PCE) of acupuncture was 58% for pain intensity (PCE = 0.58, 95% CI 0.45 to 0.71), 57% for physical function (PCE = 0.57, 95% CI -0.07 to 1.20), and 69% for fatigue (PCE = 0.69, 95% CI 0.18 to 1.21).| | ||
| + | ^Conclusion| Acupuncture showed a statistically significant difference in decreased pain intensity and fatigue in women with FM. However, the certainty of evidence was low to very low; its effects are not clinically important, and more than 50% of the overall treatment effects were not attributed to the specific effects of acupuncture.| | ||
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| + | ==== Carrasco-Vega 2024 ==== | ||
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| + | Carrasco-Vega E, Guiducci S, Nacci F, Bellando Randone S, Bevilacqua C, Gonzalez-Sanchez M, Barni L. Efficacy of physiotherapy treatment in medium and long term in adults with fibromyalgia: an umbrella of systematic reviews. Clin Exp Rheumatol. 2024 Jun;42(6):1248-1261. https://doi.org/10.55563/clinexprheumatol/ctfuqe | ||
| + | ^Objectives| To summarise the available evidence and assess the effectiveness of medium and long-term physiotherapy treatment in adults with fibromyalgia (FM).| | ||
| + | ^Methods| This systematic review was registered in PROSPERO: CRD42023388356. The databases searched were MEDLINE, PEDro, Scopus, Cinhal, LatinIndex, and Cochrane, using the following keywords: "fibromyalgia", "physiotherapy", "treatment", "therapeutic exercise", "TENS", "laser therapy" and "manual therapy." The included articles analysed treatments with active or passive physiotherapy approaches in patients with FM. The variables included structural characteristics, such as: author, publication year, research question, and main outcome variables. The data on the findings of the articles comprised the following aspects: number of participants, intervention, follow-up, results, and principal conclusions.| | ||
| + | ^Results| Thirty-three articles were analysed, with an overall PRISMA score of 18.63±3.36. The active treatment methods analysed were: movement and body awareness therapies (stretching, tai chi, yoga and Pilates); hydrotherapy; physical or aerobic exercise; and multidisciplinary therapy. The passive therapies analysed were: manual therapy; repetitive transcranial magnetic stimulation (rTMS); and other therapies (hyperbaric oxygen therapy, vibration therapy, virtual reality, transcutaneous electric nervous stimulation (TENS), pain neuroscience education, and **acupuncture**). Evidence was found on the positive effect of physiotherapy treatment on the signs and symptoms of fibromyalgia, such as pain, impairment of physical capacity and worse quality of life.| | ||
| + | ^Conclusions| The effectiveness of the active and passive therapies analysed in the management of the symptoms and signs of the disease was positive in most of the studies. However, more specific descriptions of the treatment protocol, frequency, intensity and treatment dose are required to reach a consensus, as well as primary studies for a more extended follow-up period to better evaluate long-term effects.| | ||
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| ==== Perry 2017 ☆ ==== | ==== Perry 2017 ☆ ==== | ||
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| + | ==== Chinese Guidelines on Nonpharmacological Treatment of Fibromyalgia 2025 ⊕ ==== | ||
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| + | Li X, Pan H, Wang L, Zhou Q, Ma Y, Wang Q, Wang M, Xie Z, Li H, Chen L, Huang L, Chen Y, Wen C. Guidelines on Treating Fibromyalgia With Nonpharmacological Therapies in China. J Evid Based Med. 2025 Jun;18(2):e70044. https://doi.org/10.1111/jebm.70044 | ||
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| + | | We recommend acupuncture to patients with fibromyalgia over no interventions (strong recommendation, moderate certainty of evidence).| | ||
| + | ==== Centers for Disease Control and Prevention (CDC, USA) 2022 ⊕==== | ||
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| + | Dowell D, Ragan KR, Jones CM, Baldwin GT, Chou R. CDC Clinical Practice Guideline for Prescribing Opioids for Pain - United States, 2022. MMWR Recomm Rep. 2022 Nov 4;71(3):1-95. https://doi.org/10.15585/mmwr.rr7103a1 | ||
| + | | Clinicians should recommend appropriate noninvasive nonpharmacologic approaches to help manage chronic pain, such as [...] cognitive behavioral therapy, myofascial release massage, mindfulness practices, tai chi, qigong, **acupuncture**, and multidisciplinary rehabilitation for// fibromyalgia//. | | ||
| ==== American Academy of Family Physicians (AAFP, USA) 2021 ⊕ ==== | ==== American Academy of Family Physicians (AAFP, USA) 2021 ⊕ ==== | ||
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| |Chronic pain : Non-opioid analgesics, physical therapy, cognitive behavioral therapy, rehabilitation, exercise, integrative medical therapies (e.g., yoga, relaxation, tai chi, massage, and **acupuncture**), opioids on a case-by-case basis. \\ Acupuncture : indications Low back pain, **fibromyalgia**, chronic headache, neck pain. Magnitude to benefit pain and function: small to moderate. | | |Chronic pain : Non-opioid analgesics, physical therapy, cognitive behavioral therapy, rehabilitation, exercise, integrative medical therapies (e.g., yoga, relaxation, tai chi, massage, and **acupuncture**), opioids on a case-by-case basis. \\ Acupuncture : indications Low back pain, **fibromyalgia**, chronic headache, neck pain. Magnitude to benefit pain and function: small to moderate. | | ||
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| + | ==== Department of Veterans Affairs Department of Defense (VA/DoD, USA) 2021 ⊕ ==== | ||
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| + | VA/DoD clinical practice guideline for the management of chronic multisymptom illness. Department of Veterans Affairs Department of Defense. 2021:117P. [112589]. [[https://www.healthquality.va.gov/guidelines/MR/cmi/VADoDCMICPG508.pdf|URL]] | ||
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| + | |We suggest offering manual acupuncture as part of the management of patients with CMI and symptoms consistent with fibromyalgia. (Weak for / Reviewed, New-replaced).| | ||
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| + | ==== Italian Society for Rheumatology (SIR, Italy) 2021 ⊕ ==== | ||
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| + | Ariani A, Bazzichi L, Sarzi-Puttini P, Salaffi F, Manara M, Prevete I, Bortoluzzi A, Carrara G, Scirè CA, Ughi N, Parisi S. The Italian Society for Rheumatology clinical practice guidelines for the diagnosis and management of fibromyalgia Best practices based on current scientific evidence. Reumatismo. 2021 Aug 3;73(2):89-105. https://doi.org/10.4081/reumatismo.2021.1362 | ||
| + | |||
| + | |//Recommendation //15: acupuncture (level 1, grade A)| | ||
| + | ==== Ministère de la Santé et des Services, Gouvernement du Québec (MSSS, Canada) 2021 ⊕ ==== | ||
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| + | Algorithme de prise en charge de la fibromyalgie. Ministère de la Santé et des Services. [[https://publications.msss.gouv.qc.ca/msss/document-001056/|URL]] | ||
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| + | |Acupuncture. Une récente revue Cochrane conclue que l’acupuncture améliore la douleur, la rigidité, le bien-être général et la fatigue par rapport au non-traitement (évidence faible-modérée), mais tout autant que le placebo. L’acupuncture avec stimulation électrique serait plus efficace que le seuil aiguilletage. L’effet perdure à 1 mois, mais pas à 6 mois. Cette modalité semble sécuritaire et peut être recommandée aux patients souffrant de fibromyalgie. Combinée à l’exercice, elle pourrait potentialiser l’effet sur la douleur (Deare et autres, 2013).| | ||
| ==== Agency for Healthcare Research and Quality (ARQ, USA) 2020 ⊕ ==== | ==== Agency for Healthcare Research and Quality (ARQ, USA) 2020 ⊕ ==== | ||
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| + | ==== Finnish Medical Association, Finnish Society of Anaesthesiology and Finnish General Practitioner (Finland) 2017 Ø ==== | ||
| + | [Pain]. Duodecim of the Finnish Medical Association, Finnish Society of Anaesthesiology and Finnish General Practitioner. 2017:23P. [219464]. [[https://www.kaypahoito.fi/xmedia/hoi/hoi50103.pdf|URL]] | ||
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| + | |There is no reliable research evidence on the effect of acupuncture on pain in patients with fibromyagia. | | ||
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| + | |||
| + | ==== Japan College of Fibromyalgia Investigation, Japan Agency for Medical Research and Development (JCFI, JAMRD, Japan) 2017 ⊕ ==== | ||
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| + | Japan College of Fibromyalgia Investigation, Japan Agency for Medical Research and Development. Sen-i Kintsu Syo Shinryo Gaidorain [Clinical Practice Guideline For Fibromyalgia]. Jpn Med J . 2017 [in Japanese] . | ||
| + | //Cited by// Okawa Y, Yamashita H, Masuyama S, Fukazawa Y, Wakayama I. Quality assessment of Japanese clinical practice guidelines including recommendations for acupuncture. Integr Med Res. 2022 Sep;11(3):100838. https://doi.org/10.1016/j.imr.2022.100838 | ||
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| + | | Fibromyalgia. Acupuncture: Propose to do | | ||
| ==== Israeli Rheumatology Association (Israel) 2013 ∅==== | ==== Israeli Rheumatology Association (Israel) 2013 ∅==== | ||
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| + | - **Zheng 2022**: Zhou T. Effect of Acupuncture on Pain, Fatigue, Sleep, Physical Function, Stiffness, Well-Being, and Safety in Fibromyalgia: A Systematic Review and Meta-Analysis. J Pain Res. 2022;15:315-329. | ||
| + | - **Sarmiento-Hernández**: Sarmiento-Hernández I, Pérez-Marín MLÁ, Nunez-Nagy S, Pecos-Martín D, Gallego-Izquierdo T, Sosa-Reina MD. Effectiveness of Invasive Techniques in Patients with Fibromyalgia: Systematic Review and Meta-Analysis. Pain Med. 2020;21(12):3499-3511. [212223]. | ||
| - **Kim 2019**: Kim J, Kim SR, Lee H, Nam DH. Comparing Verum and Sham Acupuncture in Fibromyalgia Syndrome: A Systematic Review and Meta-Analysis. Evid Based Complement Alternat Med. 2019:8757685. [199574]. | - **Kim 2019**: Kim J, Kim SR, Lee H, Nam DH. Comparing Verum and Sham Acupuncture in Fibromyalgia Syndrome: A Systematic Review and Meta-Analysis. Evid Based Complement Alternat Med. 2019:8757685. [199574]. | ||
| - **Zhang 2019**: Zhang XC, Chen H, Xu WT, Song YY, Gu YH, Ni GX. Acupuncture therapy for fibromyalgia: a systematic review and meta-analysis of randomized controlled trials. J Pain Res. 2019;12:527-542. [193278]. | - **Zhang 2019**: Zhang XC, Chen H, Xu WT, Song YY, Gu YH, Ni GX. Acupuncture therapy for fibromyalgia: a systematic review and meta-analysis of randomized controlled trials. J Pain Res. 2019;12:527-542. [193278]. | ||
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| - | | | **RCT** | **Comparator** | **Sources** | | + | | | **RCT** | **Comparator** | | |
| - | ^ 2018 | Karatay S , Okur SC , Uzkeser H , Yildirim K , Akcay F. Effects of Acupuncture Treatment on Fibromyalgia Symptoms, Serotonin, and Substance P Levels: A Randomized Sham and Placebo-Controlled Clinical Trial. Pain Med. 2018;19(3):615-628. [196085]. | Sham | Kim 2019 [32], Zhang 2019 [20] | | + | ^ 2024 | Moawd SA, Abdelhalim EHN, Ibrahim AM. A comparison between the effects of vibration exercise and needle therapy on fibromyalgia symptoms and well-being in community-dwelling older adults: A randomized control study. Geriatr Nurs. 2024 Sep-Oct;59:485-490. https://doi.org/10.1016/j.gerinurse.2024.07.040 | | Acudoc2 | |
| - | ^ 2017 | Ugurlu FG, Sezer N, Aktekin L, Fidan F, Tok F, Akkuş S. The effects of acupuncture versus sham acupuncture in the treatment of fibromyalgia: a randomized controlled clinical trial. Acta Reumatol Port. 2017;42(1):32-37. [32868]. | Sham | Kim 2019 [33], Zhang 2019 [19] | | + | ^ 2023 | Moreira RM, Rosário RC, Boggiss ÉA, Lima RA, Silva PA, Silva KPD, Farias CL, Santos VQD, Silva JRTD, Simões RP, Terra AMSV, Santos ATS. Effect of Systemic and Auricular Acupuncture with a 2/100 Hz Frequency and Nogier Frequency in Fibromyalgia: a Randomized Clinical Trial, Pilot Study. J Acupunct Meridian Stud. 2023 Aug 31;16(4):139-151. https://doi.org/10.51507/j.jams.2023.16.4.139 | | Acudoc2 | |
| - | ^ 2016 | Vas J, Santos-Rey K, Navarro-Pablo R, Modesto M, Aguilar I, Campos MÁ, Aguilar-Velasco JF, Romero M, Párraga P, Hervás V, Santamaría O, Márquez-Zurita C, Rivas-Ruiz F. Acupuncture for fibromyalgia in primary care: a randomised controlled trial. Acupuncture in Medicine. 2016;34(4):257-66. [191719]. | Sham | Kim 2019 [30], Zhang 2019 [18] | | + | ^ 2021 | Mawla I, Ichesco E, Zöllner HJ, et al. Greater somatosensory afference with acupuncture increases primary somatosensory connectivity and alleviates fibromyalgia pain via insular γ-aminobutyric acid: a randomized neuroimaging trial. Arthritis Rheumatol. 2021;73(7):1318–1328. | Sham | Acudoc2 | |
| - | ^ 2014 | Stival RS, Cavalheiro PR, Stasiak CE, Galdino DT, Hoekstra BE, Schafranski MD. [Acupuncture in fibromyalgia: a randomized, controlled study addressing the immediate pain response]. Rev Bras Reumatol. 2014;54(6):431-6. [190120]. | Sham | Kim 2019 [31], Zhang 2019 [26] | | + | ^ 2020 | Garrido-Ardila EM, González-López-Arza MV, Jiménez-Palomares M, García-Nogales A, Rodríguez-Mansilla J. Effectiveness of acupuncture vs. core stability training in balance and functional capacity of women with fibromyalgia: a randomized controlled trial. Clin Rehabil. 2020 May;34(5):630-645. https://doi.org/10.1177/0269215520911992 | | Acudoc2 | |
| - | ^ 2013 | Harte SE, Clauw DJ, Napadow V, Harris RE. Pressure pain sensitivity and insular combined glutamate and glutamine (GLX) are associated with subsequent clinical response to sham but not traditional acupuncture in patients who have chronic pain. Medical Acupuncture. 2013;25(2):154-160. [170039]. | Sham | Zhang 2019 [27] | | + | | | Schweiger V, Secchettin E, Castellani C, Martini A, Mazzocchi E, Picelli A, Polati E, Donadello K, Valenti MT, Dalle Carbonare L. Comparison between Acupuncture and Nutraceutical Treatment with Migratens® in Patients with Fibromyalgia Syndrome: A Prospective Randomized Clinical Trial. Nutrients. 2020 Mar 19;12(3):821. https://doi.org/10.3390/nu12030821 | | Acudoc2 | |
| - | ^ 2012 | Hadianfard MJ, Hosseinzadeh Parizi M. A randomized clinical trial of fibromyalgia treatment with acupuncture compared with fluoxetine. Iran Red Crescent Med J. 2012;14(10):631-40. [169909]. | Fluoxetine | Cao 2013 [18], exclu Zhang 2019 ("Different treatment period. Acupuncture group received therapy for 2 weeks and control group received fluoxetine orally for 8 weeks") | | + | ^ 2018 | Karatay S , Okur SC , Uzkeser H , Yildirim K , Akcay F. Effects of Acupuncture Treatment on Fibromyalgia Symptoms, Serotonin, and Substance P Levels: A Randomized Sham and Placebo-Controlled Clinical Trial. Pain Med. 2018;19(3):615-628. [196085]. | Sham | Zheng 2022, Kim 2019, Zhang 2019 | |
| - | | | Liu SJ. [Clinical study on treating fibromyalgia syndrome with acupuncture and point injection]. [M.S. thesis], Hubei University of Traditional Chinese Medicine. 2012. | Amitriptyline | Cao 2013 [24] | | + | | | Mist SD, Jones KD. Randomized Controlled Trial of Acupuncture for Women with Fibromyalgia: Group Acupuncture with Traditional Chinese Medicine Diagnosis-Based Point Selection. Pain Med. 2018 Sep 1;19(9):1862-1871. https://doi.org/10.1093/pm/pnx322 | | Acudoc2 | |
| - | ^ 2010 | Gong Wei-Zhi, Wang Yu-Qi. [Observations on the therapeutic effect of acupuncture on fibromyalgia syndrome]. Shanghai Journal of Acupuncture and Moxibustion. 2010;29(11):725. [179722]. | Amitriptyline | Zhang 2019 [28], Cao 2013 [17], exclu Deare 2013 ("Article in Chinese"). | | + | ^ 2017 | Ugurlu FG, Sezer N, Aktekin L, Fidan F, Tok F, Akkuş S. The effects of acupuncture versus sham acupuncture in the treatment of fibromyalgia: a randomized controlled clinical trial. Acta Reumatol Port. 2017;42(1):32-37. [32868]. | Sham | Zheng 2022, Kim 2019, Zhang 2019 | |
| - | | | Gou AS, Li AH. Clinical observation on therapeutic effect of electroacupuncture combining TDP irradiation on fibromyalgia syndrome 36 cases. Jiao Tong Yi Xue. 2010; 24(4): 410-411. | Fluoxetine | Yang 2014 [29], exclu Deare 2013 ("Article in Chinese"). | | + | | | Zucker NA, Tsodikov A, Mist SD, et al. Evoked pressure pain sensitivity is associated with differential analgesic response to verum and sham acupuncture in fibromyalgia. Pain Med. 2017;18(8):1582–1592. | | | |
| - | | | Itoh K, Kitakoji H. Effects of acupuncture to treat fibromyalgia: a preliminary randomised controlled trial. Chinese Medicine. 2010;5(1):11. [155309]. | No intervention | Deare 2013, exclu Zhang 2019 ("Five acupuncture treatments vs ten acupuncture treatments") | | + | ^ 2016 | Vas J, Santos-Rey K, Navarro-Pablo R, Modesto M, Aguilar I, Campos MÁ, Aguilar-Velasco JF, Romero M, Párraga P, Hervás V, Santamaría O, Márquez-Zurita C, Rivas-Ruiz F. Acupuncture for fibromyalgia in primary care: a randomised controlled trial. Acupuncture in Medicine. 2016;34(4):257-66. [191719]. | Sham | Zheng 2022, Kim 2019, Zhang 2019 | |
| - | | | Jang ZY, Li CD, Qiu L, Guo JH, He LN, Yue Y, Li FZ, Qin WY. [Combination of acupuncture, cupping and medicine for treatment of fibromyalgia syndrome: a multi-central randomized controlled trial]. Chinese Acupuncture and Moxibustion. 2010;30(4):265-9. [155708]. | Amitriptyline / Seroxat | Cao 2013 [21], exclu Zhang 2019 (control), exclu Deare 2013 ("Article in Chinese. Invalid control (acupuncture + cupping +Westernmedicine versus acupuncture + cupping versus+ Western medicine"). | | + | ^ 2014 | Stival RS, Cavalheiro PR, Stasiak CE, Galdino DT, Hoekstra BE, Schafranski MD. [Acupuncture in fibromyalgia: a randomized, controlled study addressing the immediate pain response]. Rev Bras Reumatol. 2014;54(6):431-6. [190120]. | Sham | Zheng 2022, Kim 2019, Zhang 2019 | |
| - | | | Ruan YD, Wei WZ, Hong XT, and Yang XH. [Clinical observation of moxibustion for fibromyalgia]. in Proceedings of the 11th Acupuncture Symposium of Guangdong Province. 2010. | Amitriptyline | Cao 2013 [26] | | + | ^ 2013 | Harte SE, Clauw DJ, Napadow V, Harris RE. Pressure pain sensitivity and insular combined glutamate and glutamine (GLX) are associated with subsequent clinical response to sham but not traditional acupuncture in patients who have chronic pain. Medical Acupuncture. 2013;25(2):154-160. [170039]. | Sham | Zheng 2022, Zhang 2019 | |
| - | ^ 2009 | Harris RE, Zubieta JK, Scott DJ, Napadow V, Gracely RH, Clauw DJ. Traditional Chinese acupuncture and placebo (sham) acupuncture are differentiated by their effects on mu-opioid receptors (MORS). Neuroimage. 2009;47(3):1077-1085. [153312]. | Sham | Kim 2019 [41], Zhang 2019 [29], Deare 2013 | | + | ^ 2012 | Hadianfard MJ, Hosseinzadeh Parizi M. A randomized clinical trial of fibromyalgia treatment with acupuncture compared with fluoxetine. Iran Red Crescent Med J. 2012;14(10):631-40. [169909]. | Fluoxetine | Cao 2013 [18], exclu Zhang 2019 ("Different treatment period. Acupuncture group received therapy for 2 weeks and control group received fluoxetine orally for 8 weeks") | |
| - | ^ 2008 | Harris RE, Sundgren PC, Pang Y, Hsu M, Petrou M, Kim SH, Mclean SA, Gracely RH, Clauw DJ. Dynamic levels of glutamate within the insula are associated with improvements in multiple pain domains in fibromyalgia. Arthritis Rheum. 2008;58(3):903-7. [148811]. | Sham | Deare 2013, exclu de Zhang 2019 ("Data unusable; only ten patients") | | + | | | Liu SJ. [Clinical study on treating fibromyalgia syndrome with acupuncture and point injection]. [M.S. thesis], Hubei University of Traditional Chinese Medicine. 2012. | Amitriptyline | Cao 2013 [24] | |
| - | | | Targino RA, Imamura M, Kaziyama HH, Souza LP, Hsing WT, Furlan AD, Imamura ST, Azevedo Neto RS. A randomized controlled trial of acupuncture added to usual treatment for fibromyalgia. J Rehabil Med. 2008;40(7):582-8. [151018]. | Tricyclic antidepressants and exercise | Yang 2014 [32], Cao 2013 [20], Deare 2013, exlu Zhang 2019 ("Acupuncture + tricyclic antidepressants + exercise vs tricyclic antidepressants + exercise") | | + | ^ 2010 | Gong Wei-Zhi, Wang Yu-Qi. [Observations on the therapeutic effect of acupuncture on fibromyalgia syndrome]. Shanghai Journal of Acupuncture and Moxibustion. 2010;29(11):725. [179722]. | Amitriptyline | Zhang 2019 [28], Cao 2013 [17], exclu Deare 2013 ("Article in Chinese"). | |
| - | | | Wang CM. [Clinical treatment of acupuncture and semiconductor laser irradiation on fibromyalgia symptoms 28 cases]. Shi Yong Zhong Yi Nei Ke Xue Za Zhi, 2008; 22(1): 58. | Amitriptyline | Yang 2014 [27] | | + | | | Gou AS, Li AH. Clinical observation on therapeutic effect of electroacupuncture combining TDP irradiation on fibromyalgia syndrome 36 cases. Jiao Tong Yi Xue. 2010; 24(4): 410-411. | Fluoxetine | Yang 2014 [29], exclu Deare 2013 ("Article in Chinese"). | |
| - | ^ 2006 | Martin DP, Sletten CD, Williams BA, Berger IH. Improvement in fibromyalgia symptoms with acupuncture: results of a randomized controlled trial. Mayo Clin Proc. 2006;81(6):749-57. [141310]. | Sham | Kim 2019 [43], Zhang 2019 [30], Yang 2014 [25], Cao 2013 [25], Deare 2013 | | + | | | Itoh K, Kitakoji H. Effects of acupuncture to treat fibromyalgia: a preliminary randomised controlled trial. Chinese Medicine. 2010;5(1):11. [155309]. | No intervention | Deare 2013, exclu Zhang 2019 ("Five acupuncture treatments vs ten acupuncture treatments") | |
| - | | | Yao QP. [Clinical study on fibromyalgia syndrome with the acupuncture of stimulating Du channel and smoothing other channels and collaterals. [M.S. thesis]: Heilongjiang University of Traditional Chinese Medicine. 2006. | Amitriptyline | Cao 2013 [29] | | + | | | Jang ZY, Li CD, Qiu L, Guo JH, He LN, Yue Y, Li FZ, Qin WY. [Combination of acupuncture, cupping and medicine for treatment of fibromyalgia syndrome: a multi-central randomized controlled trial]. Chinese Acupuncture and Moxibustion. 2010;30(4):265-9. [155708]. | Amitriptyline / Seroxat | Cao 2013 [21], exclu Zhang 2019 (control), exclu Deare 2013 ("Article in Chinese. Invalid control (acupuncture + cupping +Westernmedicine versus acupuncture + cupping versus+ Western medicine"). | |
| - | ^ 2005 | Assefi NP, Sherman KJ, Jacobsen C, Goldberg J, Smith WR, Buchwald D. A randomized clinical trial of acupuncture compared with sham acupuncture in fibromyalgia. Ann Intern Med. 2005;143(1):10-9. [140340]. | Sham | Zhang 2019 [33], Cao 2013 [14], Deare 2013, Exclu de Kim 2019 [12] (“all of the results are not reported”) | | + | | | Ruan YD, Wei WZ, Hong XT, and Yang XH. [Clinical observation of moxibustion for fibromyalgia]. in Proceedings of the 11th Acupuncture Symposium of Guangdong Province. 2010. | Amitriptyline | Cao 2013 [26] | |
| - | | | Guo Ying, Sun Yuan-Zheng. [Clinical study on treatment of fibromyalgia syndrome with penetration needling at the back]. Chinese Acupuncture and Moxibustion. 2005;25(2):98-100. [136926]. | Amitriptyline | Zhang 2019 [31], Yang 2014 [28], Deare 2013 | | + | ^ 2009 | Harris RE, Zubieta JK, Scott DJ, Napadow V, Gracely RH, Clauw DJ. Traditional Chinese acupuncture and placebo (sham) acupuncture are differentiated by their effects on mu-opioid receptors (MORS). Neuroimage. 2009;47(3):1077-1085. [153312]. | Sham | Zheng 2022, Kim 2019, Zhang 2019, Deare 2013 | |
| - | | | Harris RE, Tian X, Williams DA, Tian TX, Cupps TR, Petzke F, Groner KH, Biswas P, Gracely RH, Clauw DJ. Treatment of fibromyalgia with formula acupuncture: investigation of needle placement, needle stimulation, and treatment frequency. Journal of Alternative and Complementary Medicine. 2005;11(4):663-71. [117483]. | Sham | Kim 2019 [21], Zhang 2019 [32] , Cao 2013 [19], Deare 2013 | | + | ^ 2008 | Harris RE, Sundgren PC, Pang Y, Hsu M, Petrou M, Kim SH, Mclean SA, Gracely RH, Clauw DJ. Dynamic levels of glutamate within the insula are associated with improvements in multiple pain domains in fibromyalgia. Arthritis Rheum. 2008;58(3):903-7. [148811]. | Sham | Deare 2013, exclu de Zhang 2019 ("Data unusable; only ten patients") | |
| - | ^ 2004 | Guo XJ, Jia J. [Comparison of therapeutic effects on fibromyalgia syndrome between dermal-neurological electric stimulation and electric acupuncture]. Zhong Hua Wu Li Yi Yu Kang Fu Za Zhi 2004; 26(2): 126-127. | Amitriptyline | Yang 2014 [31] | | + | | | Targino RA, Imamura M, Kaziyama HH, Souza LP, Hsing WT, Furlan AD, Imamura ST, Azevedo Neto RS. A randomized controlled trial of acupuncture added to usual treatment for fibromyalgia. J Rehabil Med. 2008;40(7):582-8. [151018]. | Tricyclic antidepressants and exercise | Yang 2014 [32], Cao 2013 [20], Deare 2013, exlu Zhang 2019 ("Acupuncture + tricyclic antidepressants + exercise vs tricyclic antidepressants + exercise") | |
| - | ^ 2003 | Cao JQ, Li Y. [Combination of acupuncture and antidepressant medications in treating of 56 cases of fibromyalgia], Chinese Archives of TCM. 2003;21(5):813-17. [200356]. | Seroxat | Cao 2013 [15] | | + | | | Wang CM. [Clinical treatment of acupuncture and semiconductor laser irradiation on fibromyalgia symptoms 28 cases]. Shi Yong Zhong Yi Nei Ke Xue Za Zhi, 2008; 22(1): 58. | Amitriptyline | Yang 2014 [27] | |
| - | ^ 2002 | Liu Q, Li F. [Clinical observation of acupuncture for 30 cases of fibromyalgia]. Anthology of Medicine (医学文选). 2002.21(2) | Ibuprofen | Cao 2013 [23], exclu de Zhang 2019 ('"Did not meet ACR criteria"), exclu Deare 2013 ("Article in Chinese. Did not meet ACR criteria"). | | + | ^ 2006 | Martin DP, Sletten CD, Williams BA, Berger IH. Improvement in fibromyalgia symptoms with acupuncture: results of a randomized controlled trial. Mayo Clin Proc. 2006;81(6):749-57. [141310]. | Sham | Zheng 2022, Kim 2019, Zhang 2019, Yang 2014, Cao 2013, Deare 2013 | |
| - | | | Wang SP, Wang XF, Zhang DX, et al. [Clinical observation on therapeutic effect of acupuncture treatment based on syndrome differentiation of meridians on fibromyalgia syndrome]. Chinese Acupuncture and Moxibustion. 2002;22(12):807. [110262]. | Amitriptyline, Oryzanol, Vit B1 | Yang 2014 [30], exclu de Zhang 2019 ("not an RCT"), exclu Deare 2013 ("Article in Chinese. Data unusable as no SD"). | | + | | | Yao QP. [Clinical study on fibromyalgia syndrome with the acupuncture of stimulating Du channel and smoothing other channels and collaterals. [M.S. thesis]: Heilongjiang University of Traditional Chinese Medicine. 2006. | Amitriptyline | Cao 2013 [29] | |
| - | ^ 1998 | Sprott H. Efficiency of Acupuncture in Patients with Fibromyalgia. Clin Bull Myofascial Ther. 1998;3(1):37-43. [94391]. | Sham | Cao 2013 [27], Exclu de Kim 2019 [39] (“all of the results are not reported”), exclu de Zhang 2019 '"Data unusable"), exclu Deare 2013 ("“Randomly subdivided into 3 groups”. Data unusable as shows only ’mean’ results"). | | + | ^ 2005 | Assefi NP, Sherman KJ, Jacobsen C, Goldberg J, Smith WR, Buchwald D. A randomized clinical trial of acupuncture compared with sham acupuncture in fibromyalgia. Ann Intern Med. 2005;143(1):10-9. [140340]. | Sham | Zheng 2022, Zhang 2019, Cao 2013, Deare 2013, Exclu de Kim 2019 [12] (“all of the results are not reported”) | |
| - | ^ 1992 | Deluze C, Bosia L, Zirbs A, Chantraine A, Vischer TL. Electroacupuncture in fibromyalgia : results of a controlled trial. BMJ. 1992;305(6864):1249-52. [37521] | Sham | Kim 2019 [42], Zhang 2019 [14], Yang 2014 [22] , Cao 2013 [16], Deare 2013 | | + | | | Guo Ying, Sun Yuan-Zheng. [Clinical study on treatment of fibromyalgia syndrome with penetration needling at the back]. Chinese Acupuncture and Moxibustion. 2005;25(2):98-100. [136926]. | Amitriptyline | Zhang 2019 [31], Yang 2014 [28], Deare 2013 | |
| - | ^ 1989 | Lautenschlager J , Schnorrenberger CC, Müller W. Akupunktur bei generalisierter tendomyopathie (fibromyalgie-syndrom). Deutsche Zeitschrift für Akupunktur. 1989;6:122-8. [80120]. | Sham | Cao 2013 [22], exclu Deare 2013 ("Article in German. ACR criteria not met"). | | + | | | Harris RE, Tian X, Williams DA, Tian TX, Cupps TR, Petzke F, Groner KH, Biswas P, Gracely RH, Clauw DJ. Treatment of fibromyalgia with formula acupuncture: investigation of needle placement, needle stimulation, and treatment frequency. Journal of Alternative and Complementary Medicine. 2005;11(4):663-71. [117483]. | Sham | Zheng 2022, Kim 2019, Zhang 2019 | |
| + | | | Guo XJ, Jia J. [Comparison of therapeutic effects on fibromyalgia syndrome between dermal-neurological electric stimulation and electric acupuncture]. Chinese Journal of Tissue Engineering Research 2005;(53): 171-173. | Amitriptyline | | | ||
| + | ^ 2003 | Cao JQ, Li Y. [Combination of acupuncture and antidepressant medications in treating of 56 cases of fibromyalgia], Chinese Archives of TCM. 2003;21(5):813-17. [200356]. | Seroxat | Cao 2013 [15] | | ||
| + | ^ 2002 | Liu Q, Li F. [Clinical observation of acupuncture for 30 cases of fibromyalgia]. Anthology of Medicine (医学文选). 2002.21(2) | Ibuprofen | Cao 2013 [23], exclu de Zhang 2019 ('"Did not meet ACR criteria"), exclu Deare 2013 ("Article in Chinese. Did not meet ACR criteria"). | | ||
| + | | | Wang SP, Wang XF, Zhang DX, et al. [Clinical observation on therapeutic effect of acupuncture treatment based on syndrome differentiation of meridians on fibromyalgia syndrome]. Chinese Acupuncture and Moxibustion. 2002;22(12):807. [110262]. | Amitriptyline, Oryzanol, Vit B1 | Yang 2014 [30], exclu de Zhang 2019 ("not an RCT"), exclu Deare 2013 ("Article in Chinese. Data unusable as no SD"). | | ||
| + | ^ 1998 | Sprott H. Efficiency of Acupuncture in Patients with Fibromyalgia. Clin Bull Myofascial Ther. 1998;3(1):37-43. [94391]. | Sham | Cao 2013 [27], Exclu de Kim 2019 [39] (“all of the results are not reported”), exclu de Zhang 2019 '"Data unusable"), exclu Deare 2013 ("“Randomly subdivided into 3 groups”. Data unusable as shows only ’mean’ results"). | | ||
| + | ^ 1992 | Deluze C, Bosia L, Zirbs A, Chantraine A, Vischer TL. Electroacupuncture in fibromyalgia : results of a controlled trial. BMJ. 1992;305(6864):1249-52. [37521] | Sham | Zheng 2022, Kim 2019, Zhang 2019, Yang 2014, Cao 2013, Deare 2013 | | ||
| + | ^ 1989 | Lautenschlager J , Schnorrenberger CC, Müller W. Akupunktur bei generalisierter tendomyopathie (fibromyalgie-syndrom). Deutsche Zeitschrift für Akupunktur. 1989;6:122-8. [80120]. | Sham | Cao 2013 [22], exclu Deare 2013 ("Article in German. ACR criteria not met"). | | ||
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