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acupuncture:evaluation:pediatrie:14. encephalopathie hypoxique-ischemique du nouveau-ne [24 Aug 2016 12:54]
Schvartzapel Martin [Cerebral Palsy in Children]
acupuncture:evaluation:pediatrie:14. encephalopathie hypoxique-ischemique du nouveau-ne [24 Oct 2025 18:46] (Version actuelle)
Nguyen Johan [1. Systematic reviews and Meta-Analysis]
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-====== ​Cerebral Palsy in Children ​======+/​*English:​Hypoxic Ischemic Encephalopathy in Neonate*/ 
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 +=======  Hypoxic Ischemic Encephalopathy ​in Neonate ​ =======
  
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-====== Zhang 2010 ====== 
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-Objective: The objective of this study was to systematically evaluate the effects of Traditional Chinese Medicine (TCM) therapy including acupuncture,​ tu’ina, oral herbal medicine, herbal bathing, and collateral-channels conduct therapy for treating children with cerebral palsy (CP). 
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-Methods: We included randomized controlled trials (RCTs) on TCM for children with CP. We searched the China National Knowledge Infrastructure,​ Database for Chinese Technical Periodicals,​ Chinese Biomedical Literature Database, databases of Chinese biomedical journals=Chinese Medical Current Contents, Wan Fang Data, PubMed, MEDLINE,Ò Embase, and the Cochrane Library until the end of July 2009, and searched the reference list of retrieved papers. Data were extracted by 1 author and checked for validation by another author, and data were analyzed using RevMan 4.3.2. Only one meta-analysis was performed due to the heterogeneity among the trials. Results: Thirty-five (35) RCTs involving 3286 children with CP using TCM therapy and conventional therapy (CT) including physical, occupational,​ and speech therapy, hyperbaric oxygen, cranial nerves nutrition agents, or any combination of above were included. The methodological quality was generally low in terms of allocation concealment,​ blinding, and intention-to-treat analysis. ​ 
-Meta-analysis showed acupuncture combine with CT improved activities of daily living (mean difference: 6.38, 95% confidence interval 5.15–7.61;​ p < 0.00001, n 1⁄4 160) compared with CT alone. Acupuncture plus tu’ina, or plus herbal medicine and CT showed significant beneficial effects on comprehensive function in terms of both physical and mental aspects, independence,​ and verbal function compared with CT alone. The combination of radix Astragali injection with CT showed significant benefit on gross motor function and social behavior adaptation comparing with CT. There are six trials reported adverse events that were not associated with acupuncture,​ tu’ina, and=or herbal medicine. 
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-Conclusions:​ Acupuncture with or without CT or other conventional therapy, tu’ina, herbal medicine, and collateral channels conduct treatment combined with CT may have benefit in children with CP. However, due to insufficient evidence, further rigorous trials are warranted. 
 ====== encéphalopathie hypoxique-ischémique du nouveau-né : évaluation de l'​acupuncture ====== ====== encéphalopathie hypoxique-ischémique du nouveau-né : évaluation de l'​acupuncture ======
  
  
 +===== Systematic reviews and Meta-Analysis =====
  
  
 +==== Sibrecht 2024 ====
  
-===== Wong 2013 =====+Sibrecht G, Wong MY, Shrestha R, Bruschettini M. Acupuncture for hypoxic ischemic encephalopathy in neonates. Cochrane Database Syst Rev. 2024 Dec 18;​12:​CD007968. https://​doi.org/​10.1002/​14651858.CD007968.pub3 
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 +^Background|Peripartum asphyxia affects three to five per 1000 live births, with moderate or severe hypoxic ischemic encephalopathy (HIE) occurring in 0.5 to 1 per 1000 live births, and is associated with high mortality and morbidity. Therapeutic hypothermia is an effective treatment, but alternative therapies such as acupuncture are also used.| 
 +^Objectives|To determine the benefits and harms of acupuncture (e.g. needle acupuncture with or without electrical stimulation;​ laser acupuncture;​ non-penetrating types of manual or embedded acupressure) on mortality and morbidity in neonates with HIE, compared with 1) no treatment, 2) placebo or sham treatment, 3) any pharmacologic treatment, or 4) different types of acupuncture.| 
 +^Methods|CENTRAL,​ PubMed, Embase, ClinicalTrials.gov,​ and WHO ICTRP were searched in March 2023, along with grey literature from CORDIS EU, NICE, and NHSGGC Paediatrics for Health Professionals. Reference lists of relevant articles were also screened. Randomized controlled trials (RCTs), quasi-RCTs, and cluster-randomized trials were eligible. Participants were term (≥37 weeks) or late preterm (34–36 + 6 weeks) infants ≤10 days old with peripartum asphyxia. Interventions included needle, electro-, laser, or non-penetrating acupuncture,​ compared with no treatment, sham, pharmacologic therapy, or other acupuncture types. Standard Cochrane methods were applied. Primary outcomes: all-cause mortality, major neurodevelopmental disability (18–24 months and 3–5 years), adverse events, and length of hospital stay.| 
 +^Results|**Four studies (n 464 infants)** compared acupuncture with no treatment. Sample sizes ranged from 60 to 200 participants. Three trials were conducted in China and one in Russia. None of the four studies reported on any of the prespecified primary outcomes. No ongoing studies were identified.| 
 +^Conclusions|There is limited availability of studies addressing this specific population. The included studies did not assess mortality, long-term neurodevelopmental outcomes, or adverse effects of acupuncture. No conclusions can be drawn about the benefits and harms of acupuncture for HIE in neonates. Given the current limitations,​ clinicians should approach acupuncture use in neonates with HIE cautiously, as there is no evidence supporting its routine application. The available trials assessed surrogate outcomes of limited clinical impact and failed to report key outcomes such as mortality and long-term neurodevelopmental results. Future well-designed randomized trials are essential to evaluate the efficacy and safety of acupuncture for neonatal HIE.| 
 +==== Wong 2013 ====